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Director of Research Chemistry

About Us

Anokion is focused on applying the company’s antigen-specific immune tolerance technology to reduce the immunogenicity of therapeutic proteins and to treat autoimmune and allergic diseases. As a platform technology, Anokion’s approach to antigen-specific tolerance can be translated to virtually any protein in numerous clinical indications.

Job Summary

Anokion is seeking an innovative and highly-motivated Director of Research Chemistry that will lead an exceptional team of scientists to progress our proprietary immunomodulatory platform technologies, and contribute novel chemistry advancements to our research portfolio.  Reporting directly to the Chief Scientific Officer, and as a fully engaged member of the Research Leadership team, this individual will collaborate across the whole organization, including Process Chemistry, Analytical Sciences, Pharmaceutical Development, Protein Engineering, and Immunology. This role will be responsible for Research Chemistry efforts conducted both internally at our research facility in Cambridge, and externally through a network of CMOs/CROs. The successful candidate will also provide chemistry SME input into the writing and review of regulatory submissions, collaboration communications, and intellectual property filings.

Responsibilities

  • Lead a talented team of scientists within a fast-paced and collaborative biotech environment to accomplish R&D objectives and to make valuable contributions to our innovative pipeline.
  • Devise and implement synthesis and characterization of novel compounds for IND-enabling immunological efficacy studies.
  • Serve as chemistry subject matter expert for internal project teams and external engagements with CROs and collaborators.
  • Ensure quality and integrity of data flow, analyses, scientific reporting, and record keeping.
  • Work closely with development colleagues to seamlessly move development candidates from research to CMC stage.
  • Work with scientists to maintain standards for all laboratory records, internal reports, patents, and external communications.
  • Lead the preparation of scientific reports for internal and external communications, including intellectual property filings.

Qualifications and Skills

  • PhD in Chemistry (or related field) with 10+ years in biotech or pharmaceutical environment with emphasis on supramolecular chemistry (polymers, nanoparticles, dendrimers, etc.), bioconjugate chemistry, and carbohydrate chemistry.
  • Understanding of polymer chemistry, including experience with RAFT mechanisms is a plus
  • Proven management skills and a demonstrable collaborative mindset.
  • A strong background in synthetic organic chemistry with a track record of innovation and recognized as an expert in the area of chemical synthesis.
  • Extensive experience in a translational research environment with a track record of nominating lead candidates for advancement to development stages.
  • Team player with experience working in matrixed environments. 
  • Proven ability to think creativity and independently to solve challenges as part of a cross-functional team.  
  • Proven leadership skills and experience managing high-performing research teams.
  • Experience in working with external collaborators and CROs.
  • Experience in contributing to intellectual property filings, including interacting with external legal counsel
  • Strong written and oral communication skills.
  • Track record of transitioning projects from research into development phases.
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